Research seminar - Clara Prats
Heterogeneity and intracellular compartmentalization of skeletal muscle metabolism
Research seminar with associate Professor Clara Prats, Center for Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen
During the last decades, research resources invested into understanding skeletal muscle metabolism have drastically grown due to its involvement in the development of type 2 diabetes mellitus (T2DM). In spite of this, very basic metabolic pathways, such as glycogen and lipid metabolism, and their regulation by exercise and insulin, remain elusive. With the development of new tools and methods to study skeletal muscle morphology, it has become obvious that metabolic processes and signaling pathways are highly compartmentalized events.
During the last years, our work has identified some of the mechanisms that regulate skeletal muscle glycogen and lipid metabolism by redistribution of enzymes between intracellular compartments (Prats et al., 2005;Prats et al., 2006;Prats et al., 2009), and it has also shown that transverse tubules play a key role in insulin signaling transduction (Lauritzen et al., 2006;Lauritzen et al., 2008). Recently, the development of a new method to metabolically characterize skeletal muscle fibers has revealed the existence of two clearly distinctive pools of type I muscle fibers.
In order to understand cellular processes, we need to investigate them in situ and in selected cell types. We need to be aware of the heterogeneity and organization of the studied tissue, and acknowledge the importance of intracellular compartmentalization as a regulator of cellular processes.
Thursday September 9th, 2010 at 13:30 –15:00
Auditorium 3, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen Ø
The “Molecular Physiology Group”, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen
Christian Frøsig, CFrosig@ifi.ku.dk, +45 28 75 16 17